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1.
Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.
Glia
; 64(8): 1298-313, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27158936
2.
Mixed oligomers and monomeric amyloid-ß disrupts endothelial cells integrity and reduces monomeric amyloid-ß transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model.
Biochim Biophys Acta
; 1842(9): 1806-15, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24997450
3.
Design and conduct considerations for studies in patients with hepatic impairment.
Clin Transl Sci
; 16(1): 50-61, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36176049
4.
Pharmacokinetics, safety, and tolerability of BMS-986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment.
Clin Transl Sci
; 16(10): 1791-1802, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37654022
5.
Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: in vitro, in situ and in vivo studies.
Biopharm Drug Dispos
; 33(5): 246-56, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22528033
6.
Overview of Clinical Pharmacology Packages of New Drug Applications Approved for the Treatment of Rare Diseases.
J Clin Pharmacol
; 62 Suppl 2: S72-S78, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36461747
7.
Trends in FDA Transporter-Based Post-Marketing Requirements and Commitments Over the Last Decade.
Clin Pharmacol Ther
; 112(3): 635-642, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35780478
8.
FDA Approval Summary: Nivolumab in Combination with Ipilimumab for the Treatment of Unresectable Malignant Pleural Mesothelioma.
Clin Cancer Res
; 28(3): 446-451, 2022 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34462287
9.
Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes.
J Pharmacol Toxicol Methods
; 110: 107083, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34098110
10.
FDA Approval Summary: Gilteritinib for Relapsed or Refractory Acute Myeloid Leukemia with a FLT3 Mutation.
Clin Cancer Res
; 27(13): 3515-3521, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33632926
11.
Challenges with the precise prediction of ABC-transporter interactions for improved drug discovery.
Expert Opin Drug Discov
; 13(8): 697-707, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29943645
12.
The development of biological therapies for neurological diseases: moving on from previous failures.
Expert Opin Drug Discov
; 13(4): 283-293, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29394876
13.
In vitro UGT1A1 inhibition by tyrosine kinase inhibitors and association with drug-induced hyperbilirubinemia.
Cancer Chemother Pharmacol
; 82(5): 795-802, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30105461
14.
Effect of mouse strain as a background for Alzheimer's disease models on the clearance of amyloid-ß.
J Syst Integr Neurosci
; 2(2): 135-140, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-27478623
15.
Effects of Genetic Polymorphism in CYP3A4 and CYP3A5 Genes on Tacrolimus Dose Among Kidney Transplant Recipients.
Iran J Kidney Dis
; 10(3): 156-63, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-27225724
16.
High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity.
J Alzheimers Dis
; 53(4): 1499-516, 2016 07 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27392852
17.
Orlistat limits cholesterol intestinal absorption by Niemann-pick C1-like 1 (NPC1L1) inhibition.
Eur J Pharmacol
; 762: 263-9, 2015 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26048312
18.
Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats.
ACS Chem Neurosci
; 6(5): 725-36, 2015 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25782004
19.
Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders.
Brain Res
; 1628(Pt B): 298-316, 2015 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-26187753
20.
Oleocanthal enhances amyloid-ß clearance from the brains of TgSwDI mice and in vitro across a human blood-brain barrier model.
ACS Chem Neurosci
; 6(11): 1849-59, 2015 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26348065